Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)

J Bernhardt; L Churilov; F Ellery; J Collier; J Chamberlain; P Langhorne; RI Lindley; M Moodie; H Dewey; AG Thrift; G Donnan

Journal article

Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)

J Bernhardt, L Churilov, F Ellery, J Collier, J Chamberlain, P Langhorne, RI Lindley, M Moodie, H Dewey, AG Thrift, G Donnan

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

DOI: 10.1212/WNL.0000000000002459

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Abstract

Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount of mobilization following acute stroke. Methods: Eligible patients were aged ≥ 18 years, had confirmed first (or recurrent) stroke, and were admitted to a stroke unit within 24 hours of stroke onset. Patients were randomized to receive very early and frequent mobilization, commencing within 24 hours, or usual care. We used regression analyses and Classification and Regression Trees (CART) to investigate the effect of timing and dose of mobilization on efficacy and safety outcomes, irrespective of assigned treatment group. R..

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University of Melbourne Researchers

Julie Bernhardt Author

Leonid Churilov Author

Geoffrey Donnan Author

Cathy Said Author

Related Projects (2)

RESEARCH FELLOWSHIP

Stroke affects 1 in 6 Australians and often leads to lifelong disability. This Fellowship will support A/Prof Bernhardt to: 1) complete the ..

AVERT: A large, international, randomised controlled trial testing efficacy and cost effectiveness of early and frequent mobilisation after stroke

AVERT is a large, international clinical trial that tests whether introducing early and frequent exercise helps reduce the unacceptably high..

Grants

Awarded by National Institute for Health Research

Funding Acknowledgements

The trial was supported by the National Health and Medical Research Council (NHMRC) of Australia (project grant nos.: 386201, 1041401). Additional funding was received from Chest Heart and Stroke Scotland (Res08/A114), Northern Ireland Chest Heart and Stroke, Singapore Health (SHF/FG401P/2008), The Stroke Association, UK (TSA2009/09), and the National Institute of Health Research, UK (grant no.: HTA Project 12/01/16). The Florey Institute of Neuroscience and Mental Health received support from the Victorian government via the Operational Infrastructure Support Scheme. The content of the publication is solely the responsibility of the authors and does not reflect the views of the funders.